Dr. Singh obtained his Ph.D. in Biomedical and Biochemical Sciences from McMaster University in Canada.  His research focuses on leveraging human genetics to build resources amenable to unraveling the earliest consequences of  the mutations that cause late-onset human neurological disorders, and the impact of their modifiers.  Through integrative functional assays mediated cellular state profiling, this holistic approach to dissecting the underlying disease process seeks to translate findings at the lab bench into effective clinical applications.

Questions being addressed in the lab

  1. What are the earliest consequences of HTT CAG repeat expansion at the cellular level?
  2. How can we increase the sensitivity of functional readouts to fully capture the phenotypic complexity?
  3. How can we leverage natural expression variation to gain functional insights?

Projects underway to answer these questions

  1. Human Genetics Driven Neurological Disease Modeling

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  3. Harnessing the Power of Morphological Profiling for Characterizing Genotype-Phenotype Relationship

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  5. Leveraging Natural Expression Variation for Functional Analysis

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