Receiving general direction from Dr. W. Taylor Kimberly, the research fellow will be responsible for conducting research studies related to metabolomic predictors of stroke risk. The applicant must have completed a PhD and/or MD program, and demonstrated a prior track record of taking research projects from conception to completion. A major focus will be the use of the laboratory’s liquid chromatography-tandem mass spectrometry instrument to conduct metabolite profiling in ~2,500 participants of the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. Use of existing metabolomics methods and development of new methods will be integral to the success of the work.
PRINCIPAL DUTIES AND RESPONSIBILITIES:
The successful candidate is expected to be a self-motivated team player with superb time management, organizational, and communication skills. S/he must possess a strong attention to detail, computer skills, familiarity with statistical methods, background and/or interest in research, medicine, and mass spectrometry.
Specific responsibilities include but are not limited to:
- Maintaining and overseeing regulatory documentation for research studies.
- Operating and maintaining the lab’s liquid chromatography-tandem mass spectrometry instrument (Agilent 1290 HPLC – Agilent 6495 QQQ triple quadrupole mass spectrometer).
- Data management, sample tracking and inventory upkeep
- Input and manipulate information in research databases as needed.
- Coordinate and communicate with collaborators, including data analysis and sample and data transfer.
- Participate in and present data at lab meetings and journal clubs.
- Prepare manuscripts resulting from data generated in research projects.
- Performing other job-related duties as assigned.
The Kimberly Laboratory has an opening for a postdoctoral fellow to identify novel predictors of stroke risk in the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. Recent studies in our laboratory have highlighted that metabolite profiling can identify important pathways involved in stroke recovery and stroke risk. Our laboratory recently developed a novel, high throughput metabolomics platform using our Agilent 1290 HLPC / Agilent 6495 QQQ triple quadrupole mass spectrometer. A major focus will be the use of the laboratory’s liquid chromatography-tandem mass spectrometry instrument to conduct metabolite profiling in ~2,500 participants of REGARDS cohort. Use of existing metabolomics methods and development of new methods will be integral to the success of the work.
The overall thematic focus of the Kimberly Laboratory is to develop tools to understand mechanisms of stroke risk and secondary injury after stroke. Major areas of interest include mechanisms of brain injury caused by brain edema and elucidating underlying mechanisms of stroke risk traits. We leverage both patient cohorts and animal model systems to identify novel pathways and treatments for ischemic stroke.
The Kimberly laboratory is located in a rich multi-disciplinary environment involving clinicians, bench scientists, computational biologists and statisticians in the Center for Human Genetic Research, which is located on the main campus of Massachusetts General Hospital in Boston, MA.
SKILLS & COMPETENCIES REQUIRED:
- PhD and/or MD required
- Scientific background, with proven experience in multi-tasking various assigned scientific/research projects
- Minimum of 4 years clinical or research experience.
- Time Management: Exceptional organizational skills and ability to organize time and priorities effectively, asking for direction when appropriate. Flexibility to handle multiple tasks and deadline pressures.
- Analytical Skills: Ability to conceptualize and conduct complex analysis of research data
- Critical Thinking/Decision Making: Ability to appropriately evaluate all aspects of a situation and to independently make appropriate and timely decisions.
- Interpersonal/communication: Excellent interpersonal/communications skills and a good command of English language, including medical and scientific terminology.
- Information Systems/Technology Skills: Exceptional computer skills (including operating systems, word processing, database, electronic mail, Internet, and spreadsheets).
Interested candidates should contact the principal investigator directly and include a current CV.
Taylor Kimberly, MD, PhD, Massachusetts General Hospital, Lunder 644, 55 Fruit St., Boston, MA 02114, 857-238-5644