Focus Areas in the Genomic Medicine Cycle
Major leadership positions
Director, Genomics of Public Health Initiative Co-Director, Medical and Populations Genetics Director, Genetics, Stanley Center for Psychiatric Disease
MGH Department/Division
Medicine
MGH Unit(s)
Analytic and Translational Genetics Unit
Overview
Scalable genomic analysis to learn the biological mechanisms of complex diseases.
The Neale lab focuses on uncovering the genetic risk factors of common disease, in particular through international collaboration to diversify the global representation of study participants, as well as the research community involved in such efforts. We develop statistical methods and computational tools to enable efficient and scalable analysis of the growing datasets available in genetic sequencing studies. While the approaches we develop are broadly applicable to any disease or trait, we have a strong commitment to making progress on psychiatric and neurodevelopmental disorders such as schizophrenia, bipolar disorder, autism and ADHD.
Priority Projects
- Schizophrenia Exome Sequencing Meta-Analysis (SCHEMA) – a global collaborative to generate, aggregate and harmonize sequence data to advance gene discovery for schizophrenia.
- Bipolar Exome (BipEx) collaboration — leveraged exome sequencing in over 14,000 cases to identify AKAP11 as definitive risk gene for bipolar disorder and schizophrenia.
- Populations Underrepresented in Mental Illness Association Studies (PUMAS) – an international collaboration to discover the genetic risk factors of severe mental illness in Africa and admixed populations of the Americas.
- Hail – a cloud-native toolkit for scalable genetic analysis (hail.is)
Lab Members
| Name: | Email: | Role: |
|---|---|---|
| Akras, Zade | akras [@] broadinstitute.org | Graduate Student |
| Argentieri, Austin | aargentieri [@] mgh.harvard.edu | Research Fellow |
| Cerrato, Felecia | fcerrato [@] mgb.org | Researcher |
| Chapman, Sinead | sbchapman [@] mgb.org | Non-Employee |
| Chau, Grant | gchau [@] mgh.harvard.edu | Researcher |
| Chen, Siwei | schen63 [@] mgh.harvard.edu | Research Fellow |
| Churchhouse, Claire | cchurchhouse [@] mgb.org | Researcher |
| Cui, Ran | rcui1 [@] mgh.harvard.edu | Researcher |
| Dowd, Connor | dowd [@] broadinstitute.org | Researcher |
| Goldstein, Jacqueline | jgoldstein2 [@] mgb.org | Researcher |
| Giangrande, Evan | egiangrande [@] mgb.org | Postdoctoral Fellow |
| Gupta, Rahul | rgupta22 [@] mgh.harvard.edu | Graduate Student |
| Hammond, Carla | hammond [@] atgu.mgh.harvard.edu | Program Manager |
| Highham, Ed | ehigham [@] broadinstitute.org | Researcher |
| Howrigan, Daniel | dhowrigan [@] mgb.org | Researcher |
| Ivankovic-MacGibbon, Franjo | fivankovic [@] mgh.harvard.edu | Research Fellow |
| Lazarev, Daniel | dlazarev [@] mgh.harvard.edu | PhD Student |
| Liao, Calwing | cliao5 [@] mgh.harvard.edu | Research Fellow |
| Liu, Christiana | liuyijia [@] broadinstitute.org | Researcher |
| Lu, Wenhan | welu [@] mgh.harvard.edu | Offsite Collaborator |
| Nkambule, Lethukthula Lindokuhle | lnkambule [@] mgh.harvard.edu | Offsite Collaborator |
| Olivares, Ana | aolivares-veira [@] mgb.org | Offsite Collaborator |
| Ripatti, Samuli | sripatti [@] mgh.harvard.edu | Researcher |
| Schultz, Patrick | pschultz [@] broadinstitute.org | Non-Employee |
| Sealock, Julia | jsealock [@] mgh.harvard.edu | Research Fellow |
| Sittig, Karen | ksittig [@] broadinstitute.org | Researcher |
| Vittal, Chris | cvittal [@] broadinstitute.org | Non-Employee |
| Walters, Raymond | rkwalters [@] mgh.harvard.edu | Instructor in Investigation |
| Ye, Robert (Bob) | roye [@] mgh.harvard.edu | Researcher |
| Yohannes, Mary | myohannes [@] mgh.harvard.edu | Researcher |
| Zayats, Tetyana | tzayats [@] broadinstitute.org | Researcher |
Lab/Contact Telephone
617-724-1639
Primary Email
bneale [@] broadinstitute.org
The Center for Genomic Medicine (CGM) comprises one of the largest and most vibrant hubs of genomic medicine research in the world. The CGM includes 46 faculty collaborating to define the ‘genomic medicine cycle’ – which envisages a genomics community seeking to advance research from basic genomics research to ultimately using genome information for diagnostics and targeted therapeutics. All of our investigators are faculty at Harvard Medical School, and many members of our community are also investigators at the Broad Institute of Harvard and MIT.
