Jose Florez and his group have contributed to the performance and analysis of high-throughput genomic studies in type 2 diabetes and related traits in several international consortia such as MAGIC, GENIE, DIAGRAM, T2D-GENES, AMP-CMD, SIGMA and RADIANT. He leads the genetic research efforts of the Diabetes Prevention Program and the GRADE clinical trial, and directs the Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH).

Questions being addressed in the lab

  1. What is the genetic architecture of type 2 diabetes and related traits?
  2. What is the impact of genetic variation on physiology and function?
  3. Can this information be translated into better patient care?

Projects underway to answer these questions

  1. Genome-wide association studies for type 2 diabetes

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  3. Physiological and functional characterization of variants in the SLC16A11 gene

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  5. Potential for pharmacogenetics in specific populations

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Answers Found

  1. Genetic determinants of type 2 diabetes to date, by year of publication, effect size and mode of discovery

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  3. Human glycemic response to a glipizide challenge by genotype at a type 2 diabetes-associated variant in TCF7L2

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  5. Intensive lifestyle modification abolishes the risk of type 2 diabetes conferred by genetic variants

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Highlighted Publications from the lab


Analysis of protein-coding genetic variation in 60,706 humans
August, 2016

The genetic architecture of type 2 diabetes
August, 2016