Jose Florez and his group have contributed to the performance and analysis of high-throughput genomic studies in type 2 diabetes and related traits in several international consortia such as MAGIC, GENIE, DIAGRAM, T2D-GENES, AMP-CMD, SIGMA and RADIANT. He leads the genetic research efforts of the Diabetes Prevention Program and the GRADE clinical trial, and directs the Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH).