Ranjit Singh Atwal, PhD
Dr. Singh obtained his Ph.D. in Biochemistry and Biomedical Sciences from McMaster University in Canada. His research focuses on leveraging human genetics to build resources amenable to unraveling the earliest consequences of the mutations that cause late-onset human neurological disorders, and the impact of their modifiers. Through integrative functional assays mediated cellular state profiling, this holistic approach to dissecting the underlying disease process seeks to translate findings at the lab bench into effective clinical applications.
Questions being addressed in the lab
Projects underway to answer these questions
Induced pluripotent stem cells from patients with Huntington’s disease show CAG repeat expansion associated phenotypes
Developmental alterations in Huntington’s disease neural cells. CHIP-seq in iPSC-derived neurons shows that epigenetic profiles in non-disease cells are correlated with transcriptional changes in HD.
Polyglutamine-expanded huntingtin exacerbates age-related disruption of nuclear integrity and nucleocytoplasmic transport. Expanded polyQ huntingtin disrupts neuronal nuclear envelope morphology in a dose- and age-dependent manner
Highlighted Publications from the lab
Developmental alterations in Huntington’s disease neural cells and pharmacological rescue in cells and mice