I am currently Director of Respiratory, Environmental, and Genetic Epidemiology at the Channing Laboratory, and Professor of Medicine at Harvard Medical School. In this capacity, I lead a 30-investigator, 110-person research group involved in examining the environmental exposures and genetic risk factors for the development of asthma and COPD. I am responsible for the administrative aspects of this program in respiratory and genetic epidemiology, as well as my own research. My laboratory has close working relationships with the Department of Environmental Health at the Harvard School of Public Health where I am a Professor of Environmental Health (Respiratory Biology Program), the Pulmonary Division at Brigham and Women’s Hospital and the Partners Center for Personalized Genetic Medicine (PCPGM) where I am currently the Director. I lead a 100 person group at the Partners Center who are focused on translational genomics. I have led multidisciplinary cooperative studies of asthma and COPD and I have international research experience in China, Norway, Mexico, England, Costa Rica, and the Netherlands. I am also Principal Investigator of the only training program in the Clinical and Genetic Epidemiology of Lung Diseases (T32 HL007427).

I have collaborated with a variety of investigators on cooperative studies such as the Childhood Asthma Management Program (CAMP), SHARE and EVE, and has served in an administrative capacity with the NHLBI for a variety of genetic epidemiologic programs including the Special Emphasis Panel on the Use of NHLBI Specimens, the Oversight Committee for the Collaborative Study on the Genetics of Asthma, the NHLBI Genotyping Service Study Section and the oversight panel for the Genotyping and Sequencing Service. I recently finished service on the T32 training grant review study section. I have authored or co-authored over 600 papers and co-written and co-edited four books, including a comprehensive textbook of Respiratory Genetics.

My long-standing research interests have been in the area of environmental and genetic risk factors for the development of asthma and chronic obstructive pulmonary disease (COPD). My initial work concerned the role of environmental tobacco smoke exposure in the development of asthma. I then studied the effect of airway responsiveness in populations on the development and natural history of asthma and COPD development. In 1996, I developed a strong interest in the genetics of asthma. By 2000 I was fully funded to pursue research in this area and now devote most of my research time to asthma genetics and genomics. A particular interest is translational genomics or predictive medicine, using genetic markers to better predict drug treatment response and disease outcomes. I have mentored 33 trainees over the past 25 years, all of whom still remain in academia.