Molecular Biology Research Technician – MacDonald Lab

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The MacDonald Laboratory in the Center for Genomic Medicine at Massachusetts General Hospital (MGH) is seeking a motivated, enthusiastic candidate to join our research group. Our research group investigates genetic diseases, especially neurologic disorders such as Huntington’s disease but also a variety of other disorders with colleagues, using molecular genetic and genomic methods, working with experimental models and collections of human samples. We aim to understand the root genetic basis of these disorders and the genetic factors that influence the onset and clinical disease features, in order to guide the development of therapeutics.


  • Prepares basic solutions and performs base-level procedures as assigned to perform genotyping assays in several formats (i.e. – liquid-handling, PCR amplification, etc.)
  • Maintains laboratory notebook
  • Understands and applies basic scientific techniques (i.e. follows established protocols)
  • Conducts analysis of results and may begin interpretation of results
  • Sets up and prepares routine experiments as directed
  • Prepares lab reagents, chemicals, instruments and equipment used in genotyping
  • May perform independent literature searches
  • Assists with organizing materials for publication or presentation
  • Maintains and orders supplies
  • A Research Technician II performs the duties of a Research Technician I (above) and may also:
  • Execute protocols of non-routine experiments related to genotyping and analysis methods
  • Assist the PI(s) with determining the most suitable methodology
  • Perform basic design and modification of protocols
  • Calculate, transcribe and analyze data
  • Prepare and present reports
  • Organize and summarize acquired data, using scientific and statistical techniques.
  • Organize and/or draft material for the preparation of research papers, manuscripts and other documents for publication and/or presentation.
  • Participate in the design of experiments or field work



  • Ability to work independently and as a team member
  • Good communication skills
  • Computer literacy
  • Working knowledge of clinical research protocols NOT REQUIRED REMOVE
  • Ability to perform multiple tasks independently
  • Molecular Biology skills, especially working with DNA, RNA
  • Interest in genetics

The Research Technician II should also possess:

  • Analytical skills and the ability to resolve technical problems
  • Ability to interpret acceptability of data results
  • Working knowledge of data management programs
  • Demonstrated competence in research techniques and methodologies including liquid handling robots, genome browser and other databases related to genome information required to design and trouble shoot and interpret custom genotyping assays.


  • Bachelor’s degree required.


  • New graduates with some lab experience (via course work, internships, etc.) or those without any prior research experience will be considered for the Research Technician I position outlined above.
  • Those with a minimum of 1 year of directly related work experience will be considered for a Research Technician II position.


  • A Research Technician II may serve as a team leader to lab assistants and Research Technician I’s.


EEO Statement 

Massachusetts General Hospital is an Equal Opportunity Employer.  By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged. 

Apply online here: