Post-Doctoral Research Fellow-Kleinstiver Lab

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The Kleinstiver Laboratory ( in the Center for Genomic Medicine at the Massachusetts General Hospital, Harvard Medical School, is seeking highly motivated post-doctoral fellow candidates. The Kleinstiver Laboratory develops and applies CRISPR genome editing technologies for biomedical research and the treatment of human diseases. We utilize protein engineering methods to impart desirable properties into CRISPR nucleases and base editors, and seek to translate novel and optimized reagents into clinically relevant primary cell types, including T cells and HSCs. The candidate will play an integral role in projects related to genome editing technology development and applications thereof.. The new hire will be appointed as a Research Fellow at the Massachusetts General Hospital and Post-Doc at the Harvard Medical School.

Interested candidates should submit their applications directly via email to Dr. Kleinstiver ( and include the following materials:

  1. a complete CV detailing scientific experience, publications, presentations, mentorship, etc.
  2. a detailed description of the candidate’s research interests, familiarity with genome editing technologies, and career aspirations.
  3. contact information for three (3) references, including a description of the referee’s familiarity with the candidate.


The Post-doctoral Fellow will become proficient in the following duties (examples, but not limited to): routine molecular biology (PCR, recombinant DNA cloning, bacterial transformations, etc.), biochemical techniques, mammalian cell culture, assessment of genome editing technologies in bacteria and mammalian cells, DNA sequencing methods (Sanger and Illumina next-generation sequencing), designing and executing experiments, analyzing and visualizing data, developing and optimizing genome editing assays, attending seminars and conferences, interacting with collaborators and peers, assisting with routine laboratory tasks, preparing reagents and solutions, recording experimental details and results in an electronic notebook, time management, communication skills, and presenting summaries of work or scientific papers in lab meeting and journal club, respectively.

The Post-Doctoral fellow will be situated in the MGH under the guidance and mentorship of Dr. Kleinstiver.


The ideal candidate should have received (or expect to receive soon) a Ph.D. in Biology, Biochemistry, Genomics or other closely related fields. Example skills and competencies that the candidate should be familiar with include, but are not limited to:

  • Strong proficiency in standard molecular biology techniques
  • Familiarity with genome, epigenetic, and base editing technologies
  • Experience with mammalian cell culture, including transformed cancer cell lines, primary human T cells, and/or primary human HSCs
  • Familiarity with Illumina sequencing methods and data analysis
  • A general interest in the scientific literature and staying informed of new advances
  • Experience with commonly used bioinformatics tools and databases, and other standard software
  • Evidence of a strong publication record, including first (or co-first) author of one or more peer-reviewed scientific publications
  • Excellent English verbal and written communication skills
  • Able to work both independently and in a team
  • Experience mentoring and training others
  • Exceptional organizational skills


Minimum Required:  Doctoral Degree

Preferred:  Doctoral Degree



Required: Recent PhD graduate



Interested applicants should submit their CV and contacts for references to:

Dr. Ben Kleinstiver (

EEO Statement

Massachusetts General Hospital is an Equal Opportunity Employer.  By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged.



Apply online here: