The Wheeler Laboratory in the Center for Genomic Medicine at the Massachusetts General Hospital, Harvard Medical School, is seeking a highly motivated post-doctoral fellow candidate to lead a project studying the pathogenesis of X-linked Dystonia Parkinsonism (XDP).
The Wheeler Laboratory studies Huntington’s disease and other neurodegenerative disorders caused by unstable microsatellite repeats, with a focus on mechanisms underlying the instability of the causative mutations. Recent findings that XDP is associated with a polymorphic hexanucleotide repeat tract (Bragg et al., 2017, PNAS 114(51):E11020-E11028) place XDP in this class of microsatellite expansion disorders. This is an exciting project that would be carried out in close collaboration with Dr. Laurie Ozelius of the Massachusetts Institute for Neurodegenerative Disease (MIND) and a community of investigators of the MGH Collaborative Center for XDP (CCXDP), involving molecular analyses of the XDP repeat and genetic modifier studies in patients and in iPSC-based models. The position at the Massachusetts General Hospital/Harvard Medical School, together with close access to the Broad Institute and resources in the Boston area and offer unparalleled opportunity for research in a stimulating and highly collaborative training environment at the forefront of human genetic disease research. The new hire will be appointed as a Research Fellow at the Massachusetts General Hospital and Post-Doc at the Harvard Medical School.
PRINCIPAL DUTIES AND RESPONSIBILITIES:
- Genome engineering using CRISPR-Cas9 editing
- Human iPSC culture and neuronal differentiation
- Performing molecular and genetic analyses in patient tissues and cells
- Developing novel methodologies, including single cell-based methods, for refining molecular/genetic analyses
- Preparation of written data reports, including methodology, figure preparations, written description of the study in the form of manuscripts and/or progress reports
- Disseminate results via conferences and journal publication
SKILLS & COMPETENCIES REQUIRED:
- The ideal candidate should have received (or expect to receive soon) a Ph.D. in genetics, neurobiology, molecular/cellular biology or related discipline.
- Highly motivated, versatile and collaborative, with the ability to work in a fast-paced environment, and adaptability to new innovations and shifting priorities
- A strong record of productivity as evidenced by publication in peer-reviewed scientific journals
- Excellent English verbal and written communication skills
- The ability to independently conduct hypothesis-driven research
- The ability to work effectively as part of a collaborative team
- Excellent quantitative and organizational skills
- Highly skilled in molecular biology techniques
- High level of competence in statistical analyses
- Experience in Bioinformatic analyses is a strong plus
- Experience with growing and manipulating iPSCs is preferred
Interested applicants should submit their CV and contacts for references to: Dr. Vanessa Wheeler at Wheeler@helix.mgh.harvard.edu
Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged.
Apply online here: https://partners.taleo.net/careersection/ghc/jobdetail.ftl?job=3109694