Research Fellow – Slaugenhaupt Lab

Apply online here: https://partners.taleo.net/careersection/ghc/jobdetail.ftl?job=3077799

The Slaugenhaupt and Vandenberghe labs are seeking a highly motivated post-doctoral fellow to study retinal degeneration in a new FD mouse model and to explore the therapeutic potential of a splice-targeted therapy. The Slaugenhaupt lab in the Center for Genomic Medicine (CGM) focuses on the development of new therapeutic strategies specifically targeting RNA splicing through integrated approaches combining molecular biology, genetics, genomics, animal models and computational biology. The Vandenberghe lab in the Grousbeck Gene Therapy Center focuses on developing and translating genetic therapies to the clinic with an emphasis on blindness and other neurosensory disorders.

The Research Fellow will be leading a collaborative research project aiming at characterize retinal degeneration in a phenotypic mouse model of FD and at evaluating the in vivo therapeutic effectiveness of a new splice-targeted approach based on exon specific U1 snRNAs. The Research Fellow will also be responsible for project management, the preparation of presentation materials, manuscripts and grant applications, mentoring of technologists and students, and presentations at local, national and international conferences.

The ideal candidate will have experience in:

  • Mouse husbandry, genotyping and dissections.
  • Histological and immune-histochemical techniques.
  • Molecular and cellular biology techniques including DNA, RNA, and protein isolation and  manipulation.

.      Strong communications skills are essential and the ability to work independently; lead a project and write manuscripts.

Suitable candidates should hold a Doctoral Degree with education and training in genetics, molecular biology, and neuroscience.

Required: Proven experience in molecular biology and mouse work during doctoral studies.

Preferred: Ophthalmology background.

A new hire will be working in the Simches Research Building at the Center for Genomic Medicine (CGM) as well as in the Grousbeck Gene Therapy Center. The CGM it is a multidisciplinary cross-departmental center that has as its central mission the facilitation of the genetic research cycle and development of novel therapeutics and strongly supports and encourages publications and other academic activities for career development. The Grousbeck Gene Therapy Center is an academic research center devoted to collaborative preclinical and clinical research studies, technology development, and enabling resources for the community.

 

Qualifications

 

Suitable candidates should hold a Doctoral Degree with education and training in genetics, molecular biology, and neuroscience.

Required: Proven experience in molecular biology and mouse work during doctoral studies.

Preferred: Ophthalmology background.

Contact Monica Salani if interested: MSALANI@mgh.harvard.edu

Apply online here: https://partners.taleo.net/careersection/ghc/jobdetail.ftl?job=3077799