GENERAL SUMMARY/ OVERVIEW STATEMENT:
The Walker Laboratory in the Center for Genomic Medicine at the Massachusetts General Hospital, Harvard Medical School, is seeking highly motivated post-doctoral fellow candidates to join our enthusiastic diverse team to develop cutting-edge gene editing therapies for neurofibromatosis type 1 (NF1).
The Walker Laboratory focuses primarily on NF1, a genetic disorder with an incidence of one in 3,000–4,000 people. Most adults with NF1 develop neurofibromas – benign, but often disfiguring, tumors associated with peripheral nerves. About 10% of NF1 patients develop malignant peripheral nerve sheath tumors (MPNSTs), which carry a poor prognosis and are often fatal. We utilize a combination of genetic, molecular, and biochemical approaches using both animal and human cell models to improve our mechanistic understanding of NF1 and identify therapeutic targets.
The candidate will play an integral role in projects related to developing genome editing therapeutics for individuals with NF1. The new hire will be appointed as a Research Fellow at the Massachusetts General Hospital and Post-Doc at the Harvard Medical School.
Interested applicants should contact Dr. James Walker (firstname.lastname@example.org) directly with their CV, a summary of their research accomplishments, and a brief description of research interests and career goals.
PRINCIPAL DUTIES AND RESPONSIBILITIES:
The Post-Doctoral Fellow will develop innovative gene editing strategies (such as base and prime editing) for NF1-associated tumors. The Fellow will become proficient in the following duties (examples, but not limited to): routine molecular biology (PCR, recombinant DNA cloning, bacterial transformations, etc.), biochemical techniques, mammalian cell culture (including immortalized tumor cell lines and induced pluripotent stem cells (iPSCs)), design, optimization and testing of genome editing technologies in mammalian cells, DNA sequencing methods (Sanger and Illumina next-generation sequencing), designing and executing experiments, analyzing and visualizing data, assisting with routine laboratory tasks, preparing reagents and solutions, recording experimental details and results in an electronic notebook, time management, communication skills. The Fellow will be expected to participate in lab meetings, journal clubs and attend seminars, in addition to presenting their research findings in scientific papers and at conferences. The position offers opportunities to co-mentor Research Technicians, graduate students and student interns as well as interact with collaborators and peers, and forge new collaborations.
The Post-Doctoral fellow will be situated in the MGH under the guidance and mentorship of Dr. Walker in collaboration with the laboratory of Dr. Ben Kleinstiver (also CGM, MGH).
- Doctoral Degree
- Required: Recent PhD graduate
SKILLS & COMPETENCIES REQUIRED:
- The ideal candidate should have received (or expect to receive soon) a Ph.D. in Biology, Biochemistry, Genetics, Genomics or other closely related fields
Example skills and competencies that the candidate should/could be familiar with include, but are not limited to:
- Evidence of a strong publication record, including first (or co-first) author of one or more peer-reviewed scientific publications
- Excellent English verbal and written communication skills
- Strong proficiency in standard molecular biology techniques
- Familiarity with genome, epigenetic, and base editing technologies
- Experience with mammalian cell culture
- Familiarity with next generation sequencing methods and data analysis
- A general interest in the scientific literature and staying informed of new advances
- Able to work both independently and in a team
- Experience with commonly used bioinformatics tools and databases, and other standard software
- Familiarity with metabolic and/or neurological diseases
- Experience mentoring and training others
- Exceptional organizational skills
LICENSES, CERTIFICATIONS, and/or REGISTRATIONS: N/A
SUPERVISORY RESPONSIBILITY (authority to hire, promote, or terminate): N/A
FISCAL RESPONSIBILITY: N/A