The Wheeler Laboratory in the Center for Genomic Medicine at the Massachusetts General Hospital, Harvard Medical School, is seeking highly motivated post-doctoral fellow candidates. The Wheeler Laboratory studies Huntington’s disease and other neurodegenerative disorders caused by unstable microsatellite repeats, with a focus on mechanisms underlying the instability of the causative mutations. The laboratory employs a variety of complementary approaches that include genetic modifier studies in patients, mouse models and iPSCs, CRISPR-based technologies, molecular biology, biochemistry, microscopy and single cell analyses.
The position at the Massachusetts General Hospital/Harvard Medical School, together with close access to the Broad Institute and resources in the Boston area offer unparalleled opportunity for research in a stimulating and highly collaborative training environment at the forefront of human genetic disease research. The new hire will be appointed as a Research Fellow at the Massachusetts General Hospital and Post-Doc at the Harvard Medical School.
PRINCIPAL DUTIES AND RESPONSIBILITIES:
- Genome engineering using CRISPR-Cas9 editing
- Human iPSC culture and neuronal differentiation
- Genetic experiments using mouse models
- Preparation of written data reports, including methodology, figure preparations, written description of the study in the form of manuscripts and/or progress reports
- Disseminate results via conferences and journal publication
SKILLS & COMPETENCIES REQUIRED:
- The ideal candidate should have received (or expect to receive soon) a Ph.D. in genetics, neurobiology, molecular/cellular biology or related discipline.
- Highly motivated, versatile and collaborative, with the ability to work in a fast-paced environment, and adaptability to new innovations and shifting priorities
- A strong record of productivity as evidenced by publication in peer-reviewed scientific journals
- Excellent English verbal and written communication skills
- The ability to independently conduct hypothesis-driven research
- The ability to work effectively as part of a collaborative team
- Excellent quantitative and organizational skills
- Experience with growing and manipulating iPSCs
- Experience in Bioinformatic analyses and/or mouse models is a strong plus
Interested applicants should submit their CV and contacts for references to: Dr. Vanessa Wheeler at Wheeler@helix.mgh.harvard.edu
Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged.
Apply online here: https://partners.taleo.net/careersection/ghc/jobdetail.ftl?job=3076424