Research I or II – Gusella Lab

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The Gusella Laboratory in the Center for Genomic Medicine at Massachusetts General Hospital (MGH) is seeking a motivated, enthusiastic candidate to join our research group. Our research group investigates genetic diseases, especially neurologic disorders such as Huntington’s disease but also a variety of other disorders with colleagues, using molecular genetic and genomic methods, including culture and differentiation of human induced pluripotent stem cells (iPSC). We aim to understand the root genetic basis of these disorders and the genetic factors that influence the onset and clinical features of disease in order to guide the development of therapeutics.

Please note, the functions below are representative of major duties that are typically associated with these positions. Specific responsibilities may vary based upon departmental needs. Similarly, not all duties that have been outlined will be assigned to each position.



  • Performs routine cell culture, including iPSC maintenance and differentiation according to established protocols.
  • Routinely checks medium, reagents, and plasticware for cell culture experiments.
  • Maintains frozen stocks and detailed records of cell line culture
  • Troubleshoots cell culture problems.
  • Maintains electronic laboratory notebook.
  • Performs molecular genomics procedures as assigned (i.e. DNA/RNA extraction, sample archiving, etc.).
  • Understands and applies basic scientific techniques (i.e. follows established protocols)
  • Works both independently following detailed protocols and as a team member with a wide range of lab members (i.e. postdocs, technicians, staff scientists).

A Research Technician II performs the duties of a Research Technician I (above) and may also:

  • Assist the PI with determining the most suitable methodology
  • Participate in the design of experiments.
  • Assist in training new Research Technicians and Fellows.
  • Calculate, transcribe and analyze data
  • Prepare and present reports



  • Cell culture skills, especially working with iPSC
  • Ability to work both independently and as a team member
  • Strong organizational skills
  • Ability to prioritize tasks, set deadlines, and adapt to shifting priorities in response to changing deadlines and needs of the lab.
  • Ability to perform multiple tasks independently
  • Good communication skills
  • Computer literacy
  • Interest in genetics

The Research Technician II should also possess:

  • Analytical skills and the ability to resolve technical problems
  • Ability to interpret acceptability of data results
  • Working knowledge of data management programs
  • Demonstrated competence in research techniques and methodologies including liquid handling robots, genome browser and other databases related to genome information relevant to the cell lines cultured.


  • Bachelor’s degree and experience with tissue culture required. Experience with iPSC cultures a plus.


  • Those with a minimum of 1 year of directly related work experience will be considered for a Research Technician II position.
  • New graduates with some tissue culture laboratory experience (via course work, internships, etc.) will be considered for a Research Technician I position.


  • A Research Technician II may serve as a team leader to lab assistants and Research Technician I’s.


 EEO Statement Massachusetts General Hospital is an Equal Opportunity Employer.  By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged. 






Apply online here: