GENERAL SUMMARY/ OVERVIEW STATEMENT:
The Research Scientist will work under the general direction of the PI Dr. Catarina Silva and Laboratory Director, Dr. Stephen J. Haggarty. This person is expected to perform independently and efficiently support the lab’s efforts in conducting cutting-edge research in the fields of neuroscience, human stem cell biology and chemical biology, including engaging in highly collaborative projects both internally within MGH and externally. The research efforts will contribute to ongoing projects focused on the study of neurodegenerative disease mechanisms (tauopathies) and drug discovery.
PRINCIPAL DUTIES AND RESPONSIBILITIES:
- Performs all activities involved in cell culture propagation, maintenance, cell line engineering, cell-based drug screening assays
- Performs in vitro characterization, including biochemical and molecular biological assays
- Performs and assists in various laboratory techniques and equipment to help standardize, streamline, and maintain conformance of activities, in particular protein characterization methods and cell culture techniques
- Helps with maintaining inventory of and preparation of assay- and project-related reagents
- Develops new and improved methods and assay for efficiently addressing research goals.
- Assists when needed in laboratory management and maintenance.
- Designs, executes, documents and interprets research experiments and results.
- Contributes in a consistent manner to experimental progress reports, grant applications, peer-reviewed manuscripts, and presentations at scientific forums.
- Attention to detail, consistency and regulated methodologies, and ability to work collaboratively in a dynamic, fast paced, team-oriented environment is necessary.
- Expected to maintain intellectual and interactive curiosity and commitment to position by keeping up with appropriate reading or learning of new skills.
- Extensive experience with cell culture, with preferred experience in neuronal cells culture methods required.
- Preferred experience in neurobiology and/or stem cell models of CNS disorders.
- Experience in cellular (e.g., immunofluorescence and imaging assays) and biochemical assays (e.g., western blotting, RT-PCR) preferred.
- Demonstrated ability to work independently and productively, with detailed note taking necessary.
- Ability to multi-task and work with deadlines is required.
- Strong research design and analytical skills, with demonstrated ability to problem solve desired.
- Strong training skills and ability to help trainees and students wanted.
- Bachelor’s, Master’s degree, or Ph.D. required:
- Equivalent Experience – if Bachelor’s degree – 4+ years documented experience in human stem cell biology required
- Field of Study/Additional Specialized Training: Neuroscience, human stem cell biology, chemical biology, or related fields
- 4+ years of experience in research-related field required
- Required: experience in cell culture techniques required
- Preferred: experience in stem cell models
LICENSES, CERTIFICATIONS, and/or REGISTRATIONS: Not Applicable
SUPERVISORY RESPONSIBILITY: Not Applicable
FISCAL RESPONSIBILITY: Not Applicable
- Duties will be performed in a basic and translational science research laboratory.
- Work will predominantly be on-site
EEO Statement Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged.