Research Scientist-Lee Lab

Apply online here: https://partners.taleo.net/careersection/ghc/jobdetail.ftl?job=3107511

We invite applications for a Research Scientist to develop CRISPR therapeutic strategies for Huntington’s disease. Research projects aim to evaluate mutant-specific CRISPR strategies for Huntington’s disease and refine them to test in pre-clinical models. Positions offer training in genetics, molecular biology, genome editing, and animal models.  The Research Scientist will work independently, under direction of Principle Investigator.

The successful candidate will be a results-focused, team-oriented, creative, bench scientist, able to excel in a fast-track environment. He or she must be self-motivated, detail-oriented and exhibit strong problem solving skills. In addition, the successful candidate should be a clear and effective communicator, demonstrating strong interpersonal skills to enable collaboration with project teams, peers, and management in identifying and achieving research goals.

PRINCIPAL DUTIES AND RESPONSIBILITIES: In order of importance, list essential areas of responsibility, major job duties, special projects and key objectives for this position. These items should be evaluated throughout the year and included in the written annual evaluation. This section should be completed as a bulleted list and explain how the role is performed.

  • Design, plan, and execute cell-based, biochemical, and in vivo experiments necessary to evaluate therapeutic efficacy and specificity of CRISPR strategies for Huntington’s disease.
  • Maintain iPS cell lines and differentiate into neuronal cells
  • Work with informatics and computational scientists to integrate and interpret screening and functional genomic data sets.
  • Perform detailed characterization and molecular and functional outcomes of various CRISPR target gRNAs.
  • Work with team to design and execute research plans to ensure that critical project requirements, timelines, and deliverables are met.
  • Troubleshoot and solve scientific problems independently.
  • Identify, investigate and implement new technologies based on scientific needs.
  • Effectively present results in cross-functional project teams.
  • Design, execute, and interpret research experiments.
  • Train investigators in techniques relating to small animal surgery, molecular biology, and vector construction.
  • Investigates, creates and develops new methods and technologies for research advancements
  • Assist in laboratory management.
  • Contribute to scientific literature and present research at scientific forums.

SKILLS &COMPETENCIES REQUIRED:  This section should be a bulleted list of minimum requirements explaining the skills (what the individual is trained for) and competencies (measurable as defined by the job) necessary to perform the job.

  • Excellent publication record
  • A proven record of successful interactions within multidisciplinary teams.
  • Cell-based assay development experience is required with special emphasis on functional genomic methods for target validation (CRISPR).
  • Ability to identify allele-specific CRISPR targets, and design gRNAs
  • Significant experience in cell culture techniques including use of mammalian cell lines, primary human cells, and iPSC. Skills to differentiate iPSC into neurons.  Experience working with mouse models (general surgery, stereotaxic injection, tail vein injection, retro-orbital injection) is a plus.
  • Demonstrated ability to work independently and productively.
  • Strong research design and analytical skills, with demonstrated ability to problem solve.
  • Strong teaching skills and ability to supervise trainees and students.
  • In depth knowledge of field of research

 

LICENSES, CERTIFICATIONS, and/or REGISTRATIONS:  Specify minimum credentials and clearly indicate if required or preferred.

 

Minimum Required:

Doctoral Degree

 

 

 

 

Field of Study/Additional Specialized Training:

At least 5 years of post doctoral training in CRISPR/Cas genome editing

 

WORKING CONDITIONS: A new hire will be working in a stand laboratory environment for molecular biology and cell study. Also, he or she will be working in an animal facility for mouse experiments.

Apply online here: https://partners.taleo.net/careersection/ghc/jobdetail.ftl?job=3107511