The Wheeler Laboratory in the Center for Genomic Medicine at Massachusetts General Hospital (MGH) studies human diseases that are caused by expanded microsatellite repeats, with a principal focus on Huntington’s disease (HD). We are seeking a highly motivated candidate to join our research group to work on a project aimed at identifying genetic modifiers of CAG repeat instability in HD using CRISPR-Cas9-based approaches. The project will employ a variety of skills including molecular biology, mammalian cell culture, histology, and work with mice. The ideal candidate will be highly driven, thrive in a team-based environment, have strong molecular biology and computational skills and proficiency in mammalian cell culture. Experience with mice is a plus.
PRINCIPAL DUTIES AND RESPONSIBILITIES:
Prepares basic solutions and performs base-level procedures as assigned (i.e. – pipetting, cell and tissue culture, etc.)
Maintains laboratory notebook
Understands and applies basic scientific techniques
Conducts analysis of results and may begin interpretation of results
Sets up and prepares routine experiments as directed
Prepares lab reagents, chemicals, instruments and equipment
May perform independent literature searches
Assists with organizing materials for publication or presentation
Maintains and orders supplies
A Research Technician II performs the duties of a Research Technician I (above) and may also:
Execute protocols of non-routine experiments
Assist the PI(s) with determining the most suitable methodology
Perform basic design and modification of protocols
Calculate, transcribe and analyze data
Prepare and present reports
Organize and summarize acquired data, using scientific and statistical techniques.
Organize and/or draft material for the preparation of research papers, manuscripts and other documents for publication and/or presentation.
Participate in the design of experiments or field work.
Ability to work independently and as a team member
Good communication skills
Working knowledge of clinical research protocols
Ability to perform multiple tasks independently
The Research Technician II should also possess:
Analytical skills and the ability to resolve technical problems
Ability to interpret acceptability of data results
Working knowledge of data management programs
Demonstrated competence in research techniques and methodologies
Bachelor’s degree required.
New graduates with some lab experience (via course work, internships, etc.) or those without any prior research experience will be considered for the Research Technician I position outlined above.
Those with a minimum of 1 year of directly related work experience will be considered for a Research Technician II position.