Focus Areas in the Genomic Medicine Cycle
Major leadership positions
Director of Preventive Cardiology, Massachusetts General Hospital
Paul and Phyllis Fireman Endowed Chair in Vascular Medicine, Massachusetts General Hospital
MGH Department/Division
Preventive Cardiology
MGH Unit(s)
Cardiology
Overview
Using genomics to discover the causal factors of atherosclerotic cardiovascular disease.
The Natarajan Lab focuses on the germline and somatic genetic drivers of human atherosclerosis applying advances in genomic profiling with concomitant methods development. The interdisciplinary group spans human genetics, computational biology, and clinical medicine. The lab spearheads and contributes to several research consortia, often spanning hundreds of investigators and millions of participants to achieve project goals.
Priority Projects
- Genetic Prediction: projects catalog the relevance of genetic alleles with cardiovascular disease across diverse populations and use advanced methods to generate informative genetic predictors. We investigate opportunities for using these predictors toward improved clinical outcomes.
- Genetic Discovery: projects aim to discover the heritable mechanisms of cardiovascular disease risk. These discoveries lead to new insights in cardiovascular disease biology. Furthermore, genetic mechanisms appearing to confer protection from cardiovascular disease represent highly promising therapeutic targets.
- Somatic Mosaicism: We and others have shown that some acquired mutations in blood cells represent new risk factors for cardiovascular disease. Project involve investigations to understand the mechanisms by which acquired mutations across diverse tissue types influence cardiovascular disease through multi-omics investigations.
- Clinical Research and Classical Epidemiology: projects use bioinformatic methods applied to diverse patient-derived data across to refine cardiovascular disease risk. We also use blood-based molecular profiling to glean mechanistic insights for newly discovered risk signals.
Lab Members
| Name: | Email: | Role: |
|---|---|---|
| Aguayo, Ricardo | raguayo [@] mgh.harvard.edu | Project Manager |
| Alhariri, Housam | halharir [@] broadinstitute.org | Resident |
| Bellomo, Tiffany | tbellomo [@] mgh.harvard.edu | Resident |
| Bhatnagar, Aarushi | abhatnagar2 [@] mgh.harvard.edu | Clinical Research Coordinator |
| Bhattacharya, Romit | rbhattacharya [@] mgh.harvard.edu | Attending Physician |
| Bramel, Emily | ebramel [@] mgh.harvard.edu | Postdoc |
| Busso, Jaiden | jbusso [@] mgh.harvard.edu | Clinical Research Coordinator |
| Cho, So Mi Jemma | somi [@] broadinstitute.org | Fellow |
| Clapham, Katharine | kclapham [@] broadinstitute.org | Affiliated Faculty Member |
| Corey, Sydney | sacorey [@] mgh.harvard.edu | Medical Student |
| Dron, Jacqueline | jdron [@] mgh.harvard.edu | Research Fellow |
| Eweka, Imuetiyan | ieweka [@] mgh.harvard.edu | Clinical Research Coordinator |
| Fahed, Akl | afahed [@] mbg.org | Instructor |
| Flores, Alyssa Monica | aflores9 [@] mgh.harvard.edu | Resident |
| Fraser, Yvonne | yfraser [@] mgh.harvard.edu | Program Mananger |
| Ganesh, Shriie | sganesh2 [@] mgh.harvard.edu | Clinical Research Coordinator |
| Gold, Nina B, MD | ngold [@] mgh.harvard.edu | Assistant Professor |
| Haidermota, Sara | shaidermota [@] mgh.harvard.edu | Program Manager |
| Harper, Colin | colinharper [@] hms.harvard.edu | HMS Medical Student |
| Honigberg, Michael | mhonigberg [@] mgh.harvard.edu | Assistant Professor |
| Hornsby, Whitney | whornsby [@] mgh.harvard.edu | Associate Director |
| Jowell, Amanda | ajowell [@] mgh.harvard.edu | Resident |
| Kathiresan, Nina | ninapk28 [@] sas.upenn.edu | Undergraduate Student |
| Kamineni, Himani | hkamineni [@] mgh.harvard.edu | Undergraduate Student |
| Kamineni, Meghana | mkamineni [@] mgh.harvard.edu | Medical Student |
| Khetarpal, Sumeet | skhetarpal [@] mgb.org | Fellow |
| Koyama, Satoshi | skoyama2 [@] mgh.harvard.edu | Offsite Collaborator |
| Lannery, Kim | klannery [@] mgh.harvard.edu | Clinical Research Coordinator I |
| Lee, Jiwoo | jlee256 [@] mgh.harvard.edu | Medical Student |
| Macuare, Victoria | vmacuare [@] mgb.org | Clinical Research Coordinator I |
| Mahida, Karina | kmahida [@] mgh.harvard.edu | Undergraduate Student |
| Masson, Patricia | pmasson [@] mgb.org | Research Nurse |
| Miller, Jack | jmiller90 [@] mgh.harvard.edu | Clinical Research Coordinator |
| Misra, Anika | amisra5 [@] mgh.harvard.edu | Computational Biologist |
| Nakao, Tetsushi | tnakao1 [@] bwh.harvard.edu | Sponsored Collaborator |
| Oren, Ohad | ooren [@] mgh.harvard.edu | Fellow |
| Palaniappan, Sarvesh | sarveshp [@] bu.edu | Undergraduate Student |
| Pan, Michael | mqpan [@] mgh.harvard.edu | Graduate Student |
| Paruchuri, Kaavya | kparuchuri@mgh.harvard.edu | Instructor |
| Patel, Aniruddh | apatel32 [@] mgb.org | Instructor |
| Pitafi, Sarah | spitafi [@] bwh.harvard.edu | Medical Student |
| Postupaka, Darina | dpostupaka [@] mgh.harvard.edu | Clinical Research Coordinator |
| Pournamdari, Ashley Bahareh | apournamdari [@] mgh.harvard.edu | PhD Student |
| Rajendran, Pradeep | prajendran [@] mgb.org | Resident |
| Ramesh, Ashvita | aramesh3 [@] mgh.harvard.edu | Resident |
| Rand, Soren Albertsen | sarand [@] mgh.harvard.edu | Research Fellow |
| Ravi, Akshaya | akshaya [@] broadinstitute.org | Undergraduate Student |
| Ruan, Yunfeng | yruan3 [@] mgh.harvard.edu | Researcher |
| Russo, Christine | crusso [@] mgh.harvard.edu | Project Manager |
| Sakers, Alex | asakers [@] mgb.org | MGH Resident |
| Sarma, Amy | asarma1 [@] mgb.org | Instructor |
| Selvaraj, Margaret Sunitha | msselvaraj [@] mgh.harvard.edu | Research Fellow |
| Shankar, Adyant | ashankar1 [@] mgh.harvard.edu | Undergraduate Student |
| Shim, Injeong | ishim1 [@] mgh.harvard.edu | Research Fellow |
| Small, Aeron | asmall3 [@] mgb.org | Fellow |
| Soo Hyun (Francesca) Kim | soohyun_kim [@] hms.harvard.edu | HST Medical Student |
| Surakka, Ida | isurakka [@] broadinstitute.org | Affiliated Faculty Member |
| Tian, Haodong | htian2 [@] mgh.harvard.edu | Research Fellow |
| Trinh, Michael | mntrinh [@] mgh.harvard.edu | Resident |
| Truong, Buu | btruong3 [@] mgh.harvard.edu | Graduate Student (POI) |
| Uddin, Mesbah | muddin1 [@] mgh.harvard.edu | Researcher (POI) |
| Uppal, Nishant | nuppal [@] bwh.harvard.edu | Resident |
| Urbut, Sarah | surbut [@] mgh.harvard.edu | Fellow |
| Vazquez, Lianet | lianet.vazquez [@] mgh.harvard.edu | Resident |
| Viscosi, Victoria | vviscosi [@] mgh.harvard.edu | Clinical Research Coordinator |
| Xue, Liying | xliying [@] mgh.harvard.edu | Offsite Collaborator (POI) - Broad |
| Yu, Zhi | zyu5 [@] mgh.harvard.edu | Assistant Professor |
| Zekavat, Seyedeh Maryam | seyedehm_zekavat [@] dfci.harvard.edu | Resident |
| Zhang, Selena | selena_zhang [@] hms.harvard.edu | Medical Student |
| Zheng, Neil | nzheng1 [@] bwh.harvard.edu | Resident |
| Zou, Roger | rszou [@] mgb.org | Resident |
Lab/Contact Telephone
617-724-3526
Primary Email
pnatarajan [@] mgh.harvard.edu
Lab Website
The Center for Genomic Medicine (CGM) comprises one of the largest and most vibrant hubs of genomic medicine research in the world. The CGM includes 46 faculty collaborating to define the ‘genomic medicine cycle’ – which envisages a genomics community seeking to advance research from basic genomics research to ultimately using genome information for diagnostics and targeted therapeutics. All of our investigators are faculty at Harvard Medical School, and many members of our community are also investigators at the Broad Institute of Harvard and MIT.
