Research Overview

The Massachusetts General Hospital (MGH) Center for Genomic Medicine (CGM) is leading an effort to complete the genomic medicine cycle - from genetic discoveries to mechanism to the clinic - by assessing where genomic medicine will have the greatest impact on human health, and by driving efforts to implement genomic medicine in those areas, at MGH and beyond.  The Cycle is a paradigm for disease research that begins by comparing human phenotypes and genetic variation to identify genes of importance in human disease, then moves on to characterizing the mechanisms by which the underlying DNA differences lead to disease, and is completed when the knowledge gained delivers benefit back to patients in the forms of improved diagnosis, disease management and treatments.

 

Genomic medicine refers to diagnosis, prediction, prognosis, prevention and/or treatment of disease using approaches informed or enabled by knowledge of the genome and the molecules it encodes.