Mono- and biallelic variant effects on disease at biobank scale
Your Content Goes Here Identifying causal factors for [...]
Polygenic architecture of rare coding variation across 394,783 exomes
Your Content Goes Here Both common and rare [...]
A cross-disorder dosage sensitivity map of the human genome
Your Content Goes Here Large copy number variants (CNVs) [...]
The Gene Curation Coalition: A global effort to harmonize gene-disease evidence resources
Your Content Goes Here Documenting the evidence supporting the [...]
SLALOM suggests caution with meta-analysis fine-mapping interpretation
After researchers combine multiple genome-wide association studies into a meta-analysis, they often seek causal variants using methods built for single-cohort studies.
The Center for Genomic Medicine (CGM) comprises one of the largest and most vibrant hubs of genomic medicine research in the world. The CGM includes 46 faculty collaborating to define the ‘genomic medicine cycle’ – which envisages a genomics community seeking to advance research from basic genomics research to ultimately using genome information for diagnostics and targeted therapeutics. All of our investigators are faculty at Harvard Medical School, and many members of our community are also investigators at the Broad Institute of Harvard and MIT.
