Focus Areas in the Genomic Medicine Cycle
Major leadership positions
Director in Computational Genomics and Medicine Lab
Affiliated Faculty at Stanley Center, Broad Institute
Affiliated Faculty at Harvard School of Public Health
MGH Unit(s)
Psychiatric and Neurodevelopmental Genetics Unit
MGH Dept/Division/Unit(s)
Psychiatry
Overview
Computational genomics to study the etiologic bases of brain traits and disorders.
We use computational and statistical approaches to understand the genetic bases of complex neuropsychiatric traits and mental disorders. Multivariate pathway analysis forms the backbone of our research on identifying disease risk genes and mechanisms. We also apply multi-modal data analysis integrating genomic and neuroimaging data.
Priority Projects
- Cross-disorder analysis of major psychiatric disorders: To clarify the nosologic boundaries and etiologic overlaps among mental disorders using genomic and neuroimaging data
- Genomic pleiotropy underlying pain and mental health: To elucidate neurogenetic mechanisms of pain and their impact on mental health across the lifespan
- Neurodevelopmental trajectories of child psychopathology, substance use, and suicide: To understand the etiologic bases of mental stress and suicide risk in youth
Lab Members
| Name | Role | |
|---|---|---|
| Xuyang Li | xuli [@] mgh.harvard.edu | Research Assistant |
Lab/Contact Telephone
617-643-9304
The Center for Genomic Medicine (CGM) comprises one of the largest and most vibrant hubs of genomic medicine research in the world. The CGM includes 46 faculty collaborating to define the ‘genomic medicine cycle’ – which envisages a genomics community seeking to advance research from basic genomics research to ultimately using genome information for diagnostics and targeted therapeutics. All of our investigators are faculty at Harvard Medical School, and many members of our community are also investigators at the Broad Institute of Harvard and MIT.
