This manuscript is the first to show a link between specific nucleoside metabolites and the risk of future stroke, independent of traditional stroke risk factors. In this study, CGM Investigator Taylor Kimberly and colleagues also sought to determine whether these candidates were a reflection of genes or environment through GWA studies. Their findings suggest that the top metabolites were related to environmental or behavioral patterns, ultimately leading our group to focus on potential links between diet, the gut microbiome, and stroke risk.