Focus Areas in the Genomic Medicine Cycle
MGH Department/Division
Medicine
MGH Unit(s)
ATGU
Overview
Extracting biological information from massive genomic datasets.
Our research is focused on interpreting putative disease variants in common and rare diseases to improve our understanding of human disease and the regulation of the human genome. We do so by assembling and analyzing massive public datasets of genetic variation and functional genomics, building scalable tools and methods to keep pace with the exponential growth of these data types.
Priority Projects
- Interpreting genetic variants leveraging the demographic history of human populations
- Understanding the function of human genes through the lens of natural selection
- Narrowing on causal mechanisms of disease using rare variant association data
- Aggregating and harmonizing functional genomics data to aid in interpretation of disease association data through directional perturbation of genes
Lab Members
| Name: | Email: | Role: |
|---|---|---|
| Bram Gorissen | bgorissen [@] broadinstitute.org | Senior Computational Scientist |
| Sophie Parsa | parsa [@] broadinstitute.org | Computational Associate I |
| Jeremy Guez | guez [@] broadinstitute.org | Research Fellow |
The Center for Genomic Medicine (CGM) comprises one of the largest and most vibrant hubs of genomic medicine research in the world. The CGM includes 46 faculty collaborating to define the ‘genomic medicine cycle’ – which envisages a genomics community seeking to advance research from basic genomics research to ultimately using genome information for diagnostics and targeted therapeutics. All of our investigators are faculty at Harvard Medical School, and many members of our community are also investigators at the Broad Institute of Harvard and MIT.
