Whole genome sequence analysis of blood lipid levels in >66,000 individuals
Calcific aortic stenosis is one of the most common valvular heart diseases and has no efficacious medical therapy. In a multi-ancestry genome wide association study of 14,451 individuals with calcific aortic stenosis in the Million Veteran Program, Small et al discovered 6 novel genomic regions in the disease. Novel findings included variants near CEP85L, FTO, SLMAP, CELSR2, MECOM, and CDAN1 – together implicating complex pathobiology with contributions by lipid metabolism, inflammation, cellular senescence, and adiposity.
Read more in Nature Communications
The Center for Genomic Medicine (CGM) comprises one of the largest and most vibrant hubs of genomic medicine research in the world. The CGM includes 46 faculty collaborating to define the ‘genomic medicine cycle’ – which envisages a genomics community seeking to advance research from basic genomics research to ultimately using genome information for diagnostics and targeted therapeutics. All of our investigators are faculty at Harvard Medical School, and many members of our community are also investigators at the Broad Institute of Harvard and MIT.
