Training Program Faculty
Shawn Murphy, MD, PhD
Dr. Murphy directs the team of Informatics for Integrating Biology and the Bedside (i2b2) which has allowed him to have a large impact on clinical research that makes use of data from medical records and their accompanying artifacts such as patient genomic and imaging data. He has unlocked billions of records for research both nationally and internationally by creating online, self-serve tools that connect researchers with the clinical-care data from entire enterprises. Dr. Murphy has worked to make the raw data from medical records useful by inventing new methods that establish high quality phenotypic data from these records, and utilized the resulting high-quality data in many original research studies. Much of this work is with diverse teams of medical scientists performing electronic health record (EHR)-based analysis of patient phenotypes and their association with genotypes, biomarkers, and physiologic characteristics. Dr. Murphy directs the team of Research IS and Computing at Partners HealthCare. This leverages the extensive such work he has done in the past as Director of the Research Patient Data Registry (RPDR) for Partners HealthCare System, Inc., beginning in 1999, connecting human studies investigators to vast amounts of patient clinical data. The RPDR is a large data warehouse, with 6.5 million patients and 2.2 billion rows of clinical data, serving clinical information to 1100 researchers each year. Later, as PI of the software development cores of the i2b2 grant starting in 2004, the RPDR technology was widely accepted and installed in over 120 hospitals nationally and internationally. The high throughout phenotyping and sample collection enabled by the i2b2 team, as well as many other methods they developed, resulted in nearly 50 publications by this team in the fields of depression, bipolar disease, rheumatoid disease, inflammatory bowel disease, and multiple sclerosis. He developed the ability to extend the i2b2 population analytics directly to the provider with a Strategic Health IT Advanced Research Projects (SHARP) grant from the Office of the National Coordinator, where i2b2 is extended into a national EHR infrastructure such that the integration it provides can extent into “Apps” that can run in a hospital EHR system.