Research Scientist (Drug Discovery Pipeline) | Haggarty Lab – (3235781)

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The Chemical Neurobiology Laboratory under the direction of Dr. Stephen J. Haggarty invites applications for a Research Scientist to conduct research in the fields of neuroscience, human stell cell biology and chemical biology, with a focus on neurodegenerative disease models and drug discovery. The research will include human IPSC-derived and rodent neuronal cell culture, drug treatment for phenotypic analysis with cutting-edge technologies, as well as drug trials in animal models. This individual will engage in highly collaborative projects both internally within MGH, and externally through academic and biotech partnerships.  The Research Scientist will work independently, under direction of Principle Investigators Dr. Stephen J. Haggarty and Dr. Catarina Silva, and Program Manager Dr. Surya Reis.

The successful candidate will be a results-focused, team-oriented, creative, bench scientist, able to excel in a fast-track environment. He, she, or they must be self-motivated, detail-oriented and exhibit strong problem-solving skills. In addition, the successful candidate should be a clear and effective communicator, demonstrating strong interpersonal skills to enable collaboration with project teams, peers, and management in identifying and achieving research goals.


  • Develop and implement translational studies in fields of neuroscience, human and rodent stem-cell biology, functional genomics, and in vivo rodent pharmacology
  • Focus on neuronal cell culture, small molecule assays, sample biochemical analysis processing, high-content microscopy
  • Perform detailed characterization and cellular mechanism of action studies of chemically optimized compounds.
  • Perform and assist with animal models studies
  • Help develop new methods and assays for efficiently addressing research goals.
  • Troubleshoot and solve scientific problems independently.
  • Contribute in a consistent and timely manner to experimental progress reports, peer-reviewed manuscripts and presentations at scientific forums.
  • Work with team to design and execute research plans to ensure that critical project requirements, timelines, and deliverables are met.
  • Effectively present results in cross-functional project teams.
  • Design, execute, and interpret research experiments.
  • Investigates, creates and develops new methods and technologies for research advancements
  • Assist in laboratory management, including compound management, data management, optimization of workflows


  • Extensive experience with cell culture, with preferred experience in neuronal cell culture methods.
  • Preferred experience in neurobiology and/or stem cell models of CNS disorders.
  • Experience in cellular (e.g., immunofluorescence and imaging assays) and biochemical assays (e.g., western blotting, RT-PCR) preferred.
  • Demonstrated ability to work independently and productively, with detailed note taking.
  • Ability to multi-task, work with deadlines, work in a highly evolving environment is required.
  • Strong research design and analytical skills, with demonstrated ability to problem solve.
  • Strong training skills and ability to help trainees and students.
  • A proven record of successful interactions within multidisciplinary teams.
  • In depth knowledge of field of research




  • Doctoral Degree



  • 4+ years of experience in a research-related field that includes cell culture and animal models experience.


SUPERVISORY RESPONSIBILITY (authority to hire, promote, or terminate):  Not Applicable




WORKING CONDITIONS: Research Building (while onsite)

 EEO Statement Massachusetts General Hospital is an Affirmative Action Employer.   By embracing diverse skills, perspectives and ideas, we choose to lead. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.

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